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本文报告小剂量多巴胺对早期急性肾小管坏死无尿症的疗效。小剂量多巴胺能刺激血管特异性多巴胺受体,使肾及肠系膜血管强烈扩张;中等量时可刺激心脏β肾上腺素能受体,有正性收缩能作用;大剂量时有间接拟交感作用,引起末梢血管收缩。本组患者共11例,分别因感染、出血、烧伤和中毒引起休克和尿闭,尿量少于20毫升/小时,连续3小时以上。静脉注射速尿250～500毫克,经1小时以上,尿量未能增加。用多巴胺加于生理盐水中,经注射泵以1微克/公斤体重/分的恒速,静脉注射12小时。监测尿量、中心静脉压、心率和尿钠,按中心静
This article reports the efficacy of small doses of dopamine on early acute tubular necrosis without anorexia. Small doses of dopamine can stimulate vascular-specific dopamine receptors, the renal and mesenteric vessels strongly dilate; moderate can stimulate the heart of adrenergic receptors, a positive contraction can play a role; high dose indirect sympathomimetic effect, causing Peripheral vasoconstriction. A total of 11 patients in this group, respectively, due to infection, bleeding, burns and poisoning caused by shock and urine closed, urine output of less than 20 ml / hour for more than 3 hours. Intravenous furosemide 250 ~ 500 mg, after more than 1 hour, urine output failed to increase. Dopamine was added to saline and injected intravenously at a constant rate of 1 μg / kg body weight / minute by syringe pump for 12 hours. Monitoring urine output, central venous pressure, heart rate and urinary sodium, according to the center of static