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蕃杏科生物碱Mesembrine由Bodendorf研究小组于1957年从Mesembryanthemum tortuosum中分离得到.由于其结构特征和有趣的生物活性引起大量的关注.在过去的40年间,该化合物成为合成有机化学感兴趣的目标分子之一.到目前为止,文献中报道的全合成和形式合成路线已有40多种.对其中的31种全合成及形式合成路线进行了综述.
Mesembrine from the Bodendorf group was isolated from Mesembryanthemum tortuosum in 1957. Due to its structural features and interesting biological activity, Mesembrine has attracted much attention and has been the target of interest in synthetic organic chemistry for the past 40 years So far, there are more than 40 full synthetic and formal synthetic routes reported in the literature.A total of 31 synthetic and formal synthetic routes are reviewed.