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选取38例DN早期的患者及30例正常对照组,测定血浆Hcy,同时观察DN组服用叶酸及甲钴胺3个月前后血浆Hcy、晨ALB及血清肌酐(Scr)的变化。结果DN病人血浆Hcy显著高于正常对照组(P<0.01),服用叶酸及甲钴胺治疗后,Hcy,晨尿ALB显著下降(P<0.01)。结论应用叶酸及甲钴胺可纠正高Hcy血症,并减轻Hcy对肾脏的损害。
Thirty-eight patients with early DN and 30 normal controls were enrolled in this study. Plasma Hcy was measured. Changes in plasma Hcy, morning ALB and serum creatinine (Scr) were also observed in DN group after 3 months of treatment with folic acid and mecobalamin. Results The plasma Hcy in DN patients was significantly higher than that in the normal control group (P <0.01). After treatment with folic acid and mecobalamin, the levels of Hcy and morning urine ALB were significantly decreased (P <0.01). Conclusion Folic acid and mecobalamin can be used to correct hyperhomocysteinemia and reduce the damage of Hcy to the kidneys.