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目的探讨FⅦ基因R353Q多态性及血浆FⅦa水平与PTE的相关性。方法收集肺血栓栓塞症(PTE)患者198例和对照组212例;采用PCR-PFLP检测FⅦ基因R353Q多态性,ELISA法测定血浆FⅦa水平。结果①FⅦ基因R353Q单核苷酸多态性(SNP)基因分布频率和等位基因携带频率在病例与对照组差异均无统计学意义(P>0.05)。②血浆FⅦa水平PTE组与对照组比较,差异有显著性意义(P=0.000)。③通过非条件Logistic回归模型校正后,吸烟、纤维蛋白原和血浆FⅦa水平是PTE患者的独立危险因素。结论高血浆FⅦa水平是PTE患者的独立危险因素;FⅦ基因R353Q多态性可能不是PTE患者的独立危险因素。
Objective To investigate the association between the FⅦ gene R353Q polymorphism and plasma FⅦa levels and PTE. Methods 198 cases of pulmonary thromboembolism (PTE) and 212 cases of control group were collected. The RⅦ3Q polymorphism of FⅦ gene was detected by PCR-PFLP and the level of plasma FⅦa was measured by ELISA. Results ① There was no significant difference in the distribution frequency of R353Q SNP gene and frequency of allele between FⅦ gene and control group (P> 0.05). ② Plasma FⅦa level PTE group compared with the control group, the difference was significant (P = 0.000). (3) Smoking, fibrinogen and plasma FⅦa levels were independent risk factors for PTE after adjustment by non-conditional logistic regression model. Conclusion High plasma FⅦa level is an independent risk factor for PTE. The R353Q polymorphism of FⅦ gene may not be an independent risk factor for PTE.