论文部分内容阅读
目的探讨2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)与胰岛素抵抗(IR)、血脂紊乱的关系。方法对38例T2DM合并NAFLD患者进行血脂、血糖、血压、空腹及餐后2 h血浆胰岛素(FIns、2hIns)的测定,计算胰岛素抵抗指数(HOMA-IR)、体重指数(BMI)、腰臀比(WHR),并与34例非脂肪肝糖尿病患者作比较。结果脂肪肝组甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、FIns、2hIns、HOMA-IR、BMI、WHR、ALT、γ-谷氨酰转肽酶、尿酸、舒张压的平均水平均较非脂肪肝组明显升高(P<0.05~0.01),高密度脂蛋白胆固醇水平明显降低(P<0.05)。两组血糖、糖化血红蛋白水平差异无统计学意义(P>0.05)。结论T2DM合并NAFLD较未并发脂肪肝患者存在明显的IR、脂质代谢异常及肥胖,提示IR在脂肪肝的发病中具有十分重要的地位;NAFLD可能是代谢综合征的一个组成部分。
Objective To investigate the relationship between type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) and dyslipidemia. Methods Thirty-eight T2DM patients with NAFLD were enrolled in this study. Blood lipid, blood glucose, blood pressure, fasting and postprandial plasma insulin (FIns, 2hIns) were measured and HOMA-IR, BMI, (WHR) and compared with 34 non-fatty liver diabetic patients. Results The levels of triglyceride (TG), low density lipoprotein cholesterol (LDL-C), FIns, 2hIns, HOMA-IR, BMI, WHR, ALT, γ-glutamyl transpeptidase, (P <0.05 ~ 0.01), and the level of high density lipoprotein cholesterol decreased significantly (P <0.05). The two groups of blood glucose, glycosylated hemoglobin levels were no significant difference (P> 0.05). Conclusions There is a significant IR, lipid metabolism and obesity in patients with T2DM complicated with NAFLD compared with those without NAFLD, suggesting that IR plays an important role in the pathogenesis of fatty liver. NAFLD may be a component of metabolic syndrome.