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随着我国化学工业的飞跃发展,二甲基甲酰胺(Dimethylformamide简称DMF)已被广泛地生产和使用,接触DMF的工人与日俱增。在生产过程中工人主要是经皮接触DMF,但有关DMF的经皮毒理学资料甚少。为进一步了解DMF的经皮毒性,为预防DMF中毒提出医疗预防措施的科学依据,故本文进行了DMF经皮毒性的研究。关于DMF的毒性,已有不少报导。在我们以前所作DMF吸入实验中,家兔吸入DMF317mg/M~3,每天吸入6小时,每周6天,共14周,看到从第6周家兔体重增长缓慢,血清GPT酶活性呈间断性增高,染毒结束时动物肝脏脏器重量系数显著增高。病理组织
With the rapid development of chemical industry in our country, Dimethylformamide (DMF) has been widely produced and used, and the number of workers exposed to DMF has been increasing day by day. Workers are primarily exposed to DMF in the production process, but little is known about the percutaneous toxicity of DMF. In order to further understand the transdermal toxicity of DMF and to provide a scientific basis for preventive medical measures for the prevention of DMF poisoning, this paper carried out a study on the percutaneous dermal toxicity of DMF. There have been many reports on the toxicity of DMF. In our previous DMF inhalation experiment, rabbits inhaled DMF317mg / M ~ 3, inhaled 6 hours a day, 6 days a week, a total of 14 weeks, rabbits from 6 weeks to see the slow weight gain, serum GPT enzyme activity was discontinuous Sexual increase, the end of the animal liver organ weight coefficient was significantly higher. Pathology