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N,N-二甲基氨甲酰基三甲基硅烷与一系列芳基酮、不饱和芳基酮在无水无氧、105℃、甲苯作溶剂的条件下反应,合成了α-三甲基硅氧基酰胺衍生物,收率60%~89%,其结构用元素分析、1H NMR、13C NMR和IR等方法进行了表征.烷基烷基酮、烷基芳基酮、烷基不饱和芳基酮与N,N-二甲基氨甲酰基三甲基硅烷不反应.通过研究反应的影响因素发现,反应底物酮中与羰基相连的芳环上取代基的电子效应是该加成反应的重要影响因素,芳环上取代基的给电子能力越強,反应越慢.
N, N-dimethylcarbamoyltrimethylsilane was reacted with a series of aryl ketones and unsaturated aryl ketones under the condition of anhydrous and anaerobic, 105 ℃ and toluene as solvent to synthesize α-trimethyl Siloxy amide derivatives, yield 60% ~ 89%, the structure was characterized by elemental analysis, 1H NMR, 13C NMR and IR, etc. alkyl alkyl ketone, alkylaryl ketone, alkyl unsaturated Aryl ketones and N, N-dimethylcarbamoyl trimethylsilane non-reaction.By studying the influence factors of the reaction, it is found that the electronic effect of the substituent on the aromatic ring which is connected to the carbonyl group in the reaction substrate ketone is the addition The important influencing factors of the reaction are that the stronger the electron donating ability of the substituents on the aromatic ring, the slower the reaction.