ARG1 functions as a tumor suppressor in breast cancer

• 作 者: Zhengnan Ming Zizheng Zou Kaimei Cai Yi Xu Xueyan Chen Wenjun Yi Junli Luo Zhiyong Luo
• 机 构: Molecular Biology Research Centre,Hunan Province Key Laboratory of Basic and Applied Hematology,Huna
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2020年11期
• 关键词: ARG1 breast cancer tumor suppressor p-AKT

Arginase Ⅰ(ARG1)is a cytosolic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea.The association of ARG1 with cancer has mostly been focused on the ARG1 released by tumor-associated myeloid cells in tumor microenvironment.However,the role of ARG1 expressed in cancer cells is unclear.Here,we showed that the expression of ARG1 in human breast can-cer(BC)is related to a good prognosis in BC patients.Overexpression of ARG1 suppresses BC cell proliferation and migration in vitro and xenograft tumor growth and development in mouse models.Furthermore,ARG1 expression down-regulates the expression of p-AKT,leading to the de-activation of AKT signal pathway in BC cells.Thus,our results established that in contrast to the role of ARG1 released from tumor-associated myeloid cells in tumor microenvironment that promotes tumor immune escape,ARG1 expressed in BC cells suppresses AKT signaling pathway and functions as a tumor suppressor.