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病例:患者男,50岁。因双手发凉、发绀3年,面部、双手、前臂皮肤变硬、咳嗽2年,症状加重2周于1988年1月25日入院。患者自1985年3月起,感双手发凉,遇冷后呈现苍白,指关节疼痛,手指末端变紫。半年后逐渐出现对称性手指肿胀,皮肤增厚,指关节活动受限,未引起患者注意。至1996年4月,双手、前臂皮肤肿胀加重,变硬不能提起,继之累及颜面、躯干上部,受累皮肤呈暗褐色;干咳无痰,劳累时感气短,来门诊求治。查血、尿常规正常。血沉正常。胸部x线片示肺纹理增多、增粗。心电图正常。腹部B超:肝、脾未见异常。诊为“硬皮病”。用复春片等药治疗8个月余,病情无缓解。近2周来,因未坚持服药,症状加重,感恶心、上腹痛,不思饮食,便秘与腹泻交
Case: Male patient, 50 years old. Due to both hands cool, cyanosis for 3 years, face, hands, forearm skin hardening, cough for 2 years, 2 weeks of exacerbations in January 25, 1988 admission. Patients from March 1985 onwards, feeling both hands cold, pale after the cold, pain in the joints, finger ends purple. Half a year after the gradual symmetry of finger swelling, thickening of the skin, refers to the limited joint activity, did not cause the patient’s attention. To April 1996, his hands, forearm swelling of the skin heavier, hardened can not lift, followed by involvement of the face, the upper torso, the affected skin was dark brown; dry cough without sputum, tired when feeling short of breath, to the clinic for treatment. Check blood, normal urine. ESR normal. Chest x-ray showed increased lung texture, thickening. Normal ECG. Abdominal B ultrasound: liver, spleen no abnormalities. Diagnosis as “scleroderma.” Rejuvenation tablets and other drugs used for more than 8 months, the disease did not ease. Nearly 2 weeks, because they did not adhere to medication, symptoms, nausea, abdominal pain, do not think diet, constipation and diarrhea