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血清素是致偏头痛发病的重要神经递质,其确切的机制尚不清楚。血小板具有吸收血清素的特殊结构,主要贮存在血小板致密体中。致密体外有小的活性代谢部位,可将血清素分解成5—羟基吲哚乙酸(5—HIAA)。为进一步了解血清素在偏头痛的代谢,本文测定了血小板血清素和5—HIAA含量,评价了电子显微镜下血小板致密体的数量。本组包括28例偏头痛患者(19例普通型、9例典型)和15名正常健康女性。按照专门委员会头痛分类做出诊断。受试者在研究前至少2周未用影响血小板功能的药物。均为非吸烟者。在采血前控制酪氨酸、色氨酸和血清素饮食,以尽量减少饮食的影响。偏头痛发作后至少3天开始研究。禁食后从肘
Serotonin is an important neurotransmitter that contributes to the development of migraine headaches. The exact mechanism is not yet clear. Platelets have a special structure that absorbs serotonin and is mainly stored in dense platelets. Serotonin has a small active metabolite outside the decomposition of serotonin 5-hydroxyindoleacetic acid (5-HIAA). In order to further understand the metabolism of serotonin in migraine, we measured the contents of platelet serotonin and 5-HIAA and evaluated the number of platelet densities under electron microscope. The group consisted of 28 migraineurs (19 normal, 9 typical) and 15 normal healthy women. In accordance with the specialized committee to make a diagnosis of headache classification. Subjects did not use drugs that affected platelet function at least 2 weeks prior to study. All non-smokers. Control tyrosine, tryptophan, and serotonin diets before blood sampling to minimize dietary effects. Study began at least 3 days after onset of migraine. After fasting from the elbow