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目的:分析血清同型半胱氨酸(HCY)水平检测对于心脑血管疾病临床诊疗的意义。方法:随机选取2015年1月至12月我院收治的100例心脑血管疾病患者[脑梗塞50例(脑梗塞组)、冠心病50例(冠心病组)]与50例健康体检者(对照组),检测并对比分析3组患者HCY水平。结果:治疗前冠心病组及脑梗塞组平均HCY、TG、TC、HDL-C、LDL-C水平均明显高于对照组(P<0.05),且冠心病组及脑梗塞组间均差异无统计学意义(P>0.05)。治疗后冠心病组平均HCY、TG、TC、HDL-C、LDL-C水平为(12.44±2.18)μmol/L、(1.47±1.01)mmol/L、(5.28±0.74)mmol/L、(1.29±0.17)mmol/L、(2.85±0.36)mmol/L,脑梗塞组平均HCY、TG、TC、HDL-C、LDL-C水平为(12.33±2.74)umol/L、(1.47±0.76)mmol/L、(5.30±1.32)mmol/L、(1.30±0.22)mmol/L、(2.83±0.44)mmol/L,2组HCY水平及各项血脂指标均相比本组治疗前明显改善(P<0.05),且冠心病组及脑梗塞组间均无差异、与对照组无差异(P>0.05)。结论:HCY上升是心脑血管疾病发生进展的重要危险因素,这一因素还可诱发血脂水平异常上升,及时测定分析血清HCY水平是明确心脑血管疾病情况及治疗治疗及预后工作的关键。
Objective: To analyze the significance of detecting serum homocysteine (HCY) in the clinical diagnosis and treatment of cardiovascular and cerebrovascular diseases. Methods: 100 patients with cardiovascular and cerebrovascular diseases admitted to our hospital from January to December 2015 were selected randomly (cerebral infarction: 50 cases (cerebral infarction group), coronary heart disease: 50 cases (coronary heart disease group]) and 50 healthy subjects Control group), detect and compare HCY levels in three groups. Results: The mean levels of HCY, TG, TC, HDL-C and LDL-C in CHD group and cerebral infarction group before treatment were significantly higher than those in control group (P <0.05), and there was no difference between CHD group and cerebral infarction group Statistical significance (P> 0.05). The mean levels of HCY, TG, TC, HDL-C and LDL-C in CHD group after treatment were (12.44 ± 2.18) μmol / L and 1.47 ± 1.01 mmol / L and 5.28 ± 0.74 mmol / L respectively ± 0.17) mmol / L and (2.85 ± 0.36) mmol / L respectively. The levels of HCY, TG, TC, HDL-C and LDL-C in the cerebral infarction group were (12.33 ± 2.74) (5.30 ± 1.32) mmol / L, (1.30 ± 0.22) mmol / L, (2.83 ± 0.44) mmol / L and 2 groups HCY levels and various lipid indicators were significantly improved compared with this group before treatment (P <0.05). There was no difference between coronary heart disease group and cerebral infarction group, there was no significant difference between the two groups (P> 0.05). Conclusions: The rise of HCY is an important risk factor for the progression of cardiovascular and cerebrovascular diseases. This factor can induce an abnormal increase of blood lipid levels. The timely determination and analysis of serum HCY levels is the key to clarify the situation of cardiovascular and cerebrovascular diseases, treatment, treatment and prognosis.