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目的观察不同病理特点的卵巢癌患者外周血癌胚抗原(CA)-125表达变化。方法连续选择近期接受手术治疗的卵巢癌患者74例,治疗前进行外周血CA-125标本采集,并根据手术切除标本的病理特点进行分组,比较CA-125浓度值和阳性率分布情况。结果具有中、低程度分化、Ⅲ和Ⅳ期组、淋巴结转移和瘤体≥5 cm病理特点的卵巢癌患者CA-125浓度值和阳性例数均明显高于高分化、浸润外膜无淋巴结转移和瘤体<5 cm患者(P均<0.05~0.01)。结论卵巢癌细胞分化程度、瘤体大小、FIGO临床分期及有无淋巴结转移等病理特征明确影响着患者外周血CA-125表达和阳性率情况。
Objective To observe the changes of peripheral blood carcinoembryonic antigen (CA) -125 expression in ovarian cancer patients with different pathological features. Methods Seventy-four patients with ovarian cancer undergoing surgical treatment were selected consecutively. Peripheral blood CA-125 specimens were collected before treatment and were divided into groups according to the pathological features of the resected specimens. The distribution of CA-125 concentration and positive rate were compared. Results The concentration of CA-125 and the number of positive cases in ovarian cancer patients with moderate and poor differentiation, stage Ⅲ and Ⅳ, lymph node metastasis and tumor ≥5 cm were significantly higher than those in well-differentiated and infiltrating adventitia without lymph node metastasis And tumor <5 cm patients (all P <0.05 ~ 0.01). Conclusion The differentiation of ovarian cancer cells, tumor size, FIGO clinical stage and the presence or absence of lymph node metastasis and other pathological features clearly affect the expression of CA-125 in patients with peripheral blood and the positive rate.