前列地尔对非胰岛素依赖型糖尿病病人胰岛素及血小板聚集率的影响

• 作 者: 黄珍萍 林碧 黄忠 陈远华
• 机 构: 广西壮族自治区人民医院内分泌科
• 出 处: 中国新药与临床杂志
• 发表日期: 1998年04期
• 关键词: 前列地尔 血小板聚集率 人胰岛素 胰岛素分泌 空腹胰岛素 氯化钠注射液 静脉滴注 最大聚集率 口服降糖药 血小板聚集功能

目的：探讨前列地尔对非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人胰岛素及血小板聚集率的影响。方法：应用前列地尔２００μｇ加入０．９％氯化钠注射液５００ｍＬ中静脉滴注，ｑｄ×１０ｄ，治疗５０例ＮＩＤＤＭ病人（男性２３例，女性２７例，年龄５８±ｓ１０ａ）。治疗前后测定空腹胰岛素、餐后２ｈ胰岛素及血小板聚集率。结果：前列地尔刺激胰岛素分泌增加和降低血小板聚集率。治疗后的餐后２ｈ胰岛素显著增加（Ｐ＜０．０１），血小板聚集率显著下降（Ｐ＜０．０１，Ｐ＜０．０５）。结论：前列地尔增加ＮＩＤＤＭ病人的胰岛素分泌，降低血小板聚集率

Objective: To investigate the effect of prostaglandin on insulin and platelet aggregation in non-insulin dependent diabetes mellitus (NIDDM). Methods: 50 cases of NIDDM patients (23 males and 27 females, age 58 ± s10a) were treated by intravenous infusion of alprostadil 200μg into 500mL sodium chloride injection 500ml for qd × 10d. Before and after treatment, fasting insulin, 2h postprandial insulin and platelet aggregation rate. Results: Alprostadil stimulates increased insulin secretion and decreases platelet aggregation. After 2 hours of treatment, insulin increased significantly (P <0.01) and platelet aggregation rate decreased significantly (P <0.01, P <0.05). Conclusion: Alprostadil increases insulin secretion and reduces platelet aggregation in NIDDM patients