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本文旨在检查自首次出现浮肿到进展至终末期肾衰的肾病综合征患者并测定某些临床和病理指标的预后价值。对1948年至1979年的246例首发表现为肾病综合征并经肾活检证实有肾小球病变的患者进行了随访研究。随访期为11周至33年不等,中位数为7年。患者的男女之比为2:1。两性别组间的肾小球组织病变谱相近似。平均发病年龄男性为38岁,女性为36岁。采用Kaplan-Meier生存测算法、Mantel-Cox检验以及Cox回归模型等可信的统计学方法就患者的年龄、性别,血浆肌酐浓度、舒张压和24小时尿蛋白量与继后发生终末期肾功能衰竭之间的关系作了分析。结果表明,发病后第一年所作的结局预测最好。其时的血浆肌酐浓度(P
This article aims to examine patients with nephrotic syndrome who have edema to advanced end-stage renal failure for the first time and to determine the prognostic value of certain clinical and pathologic parameters. A follow-up study of 246 patients with a first manifestation of nephrotic syndrome from 1948 to 1979 with renal glomerular lesions confirmed by renal biopsy was performed. The follow-up period ranged from 11 weeks to 33 years with a median of 7 years. The ratio of male to female patient is 2: 1. Similarity of the spectrum of glomerular lesions between the sexes was observed. The average age of onset was 38 for males and 36 for females. Using credible statistical methods such as Kaplan-Meier survival test, Mantel-Cox test, and Cox regression model, age and gender, plasma creatinine concentration, diastolic blood pressure, and 24-hour urinary protein were compared with subsequent follow-up renal function The relationship between failure was analyzed. The results show that the first year after the onset of the outcome of the best prediction. At the time of plasma creatinine concentration (P