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肿瘤易感性一直是肿瘤研究的重要课题 ,而生物转化酶类的细胞色素P4 5 0 (CYP4 5 0 )和谷胱甘肽转硫酶(GST)等由于其对环境致癌物的生物转化作用决定了个体对肿瘤的易感程度。通过介绍其中的CYP1A1、CYP2D6、CYP2E1、GSTM1和GSTT1等的基因多态性及其与机体易患肿瘤的关系 ,揭示了生物转化酶基因多态性在肿瘤易感性中的作用。国内外的研究结果表明 :CYP1A1基因多态性与肺癌的发生、CYP2E1基因多态性与食管癌的易感性均密切相关 ,GST的基因多态性虽然与多种肿瘤的易感性有关联但研究结果有的互相矛盾 ,提示机体肿瘤发生机理的复杂性。由于环境致癌物在体内需经一系列的生物转化而产生生物学效应 ,因而生物转化酶类基因多态性的联合作用在肿瘤的易感性中显得尤为重要
Tumor susceptibility has always been an important issue in tumor research, and the biotransformation enzymes such as cytochrome P450 (CYP450) and glutathione S-transferase (GST) are determined due to their bioconversion effects on environmental carcinogens. The individual’s susceptibility to tumors. By introducing the genetic polymorphisms of CYP1A1, CYP2D6, CYP2E1, GSTM1, and GSTT1, and their relationship with the body’s susceptibility to tumors, the role of the polymorphism of the invertase gene in tumor susceptibility was revealed. Research results at home and abroad show that: CYP1A1 polymorphism is closely related to the occurrence of lung cancer, CYP2E1 gene polymorphism and susceptibility to esophageal cancer. GST gene polymorphisms are associated with the susceptibility of multiple tumors The results are contradictory, suggesting that the body’s tumor mechanism is complex. Since environmental carcinogens require a series of biological transformations in vivo to produce biological effects, the combined effect of biotransformation enzyme gene polymorphisms is particularly important in the susceptibility of tumors.