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在检测乙型肝炎病毒(HBV)感染的3项基本指标(HBsAg、抗-HBc和抗-HBs)时,可发现有些标本只有单项抗-HBc阳性,却不存在HBsAg或抗-HBs。这种类型占受试者6％以上。目前测定的抗-HBc阳性结果,除极少部分假阳性以外,可以有以下解释:①急性感染后的早期恢复阶段(“窗口阶段”)。不少正在痊愈的急性HBV感染者,有一段时间中,HBsAg降低到不易测出的水平,而抗-HBs尚未出现,抗-HBc是唯一可检出的特异性HBV标志。这段时间通常持续数周,甚而数月。这时常可检出抗-HBVIgM。②抗-HBc的被动传递。抗-HBc可以通过胎盘,而HBsAg不能。携带HBsAg母亲的婴儿,通过被动传递抗体,可
In the detection of three basic indicators of hepatitis B virus (HBV) infection (HBsAg, anti-HBc and anti-HBs), some were found to have only a single anti-HBc positive but not HBsAg or anti-HBs. This type of subjects accounted for more than 6%. The current anti-HBc positive results, with very few false positives, can be explained as follows: (1) Early recovery after acute infection (“window stage”). In many acute hepatitis B patients who are recovering, HBsAg has been reduced to intractable levels for some time, but anti-HBs have not yet appeared and anti-HBc is the only specific HBV marker that can be detected. This period usually lasts for weeks or even months. Anti-HBVIgM can often be detected at this time. ② passive anti-HBc delivery. Anti-HBc can cross the placenta and HBsAg can not. Babies with HBsAg mothers can pass antibodies passively