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以亚乙基双胍、吡啶及吡啶衍生物为配体合成了[AgEn(BigH)_2]_2(SO_4)_3·7H_2O(3)、[Ag(Py)_2(N_2)_2](OH)_2(4)和[Ag(2-Apy)_3(OH)](HSO_4)·H_2O(5)三种较稳定的高价银配合物。产物结构经红外光谱、元素分析和XPS进行表征。通过最小抑菌浓度(MIC)和生长抑制曲线来检测配合物的抗菌能力,并对配合物进行光稳定测试。抗菌实验结果显示,所有的配合物在0.5μg/mL浓度下就开始对测试菌产生抑制作用,对大肠杆菌的MIC分别为10、5和5μg/mL,对金黄色葡萄球菌的MIC为40、20和20μg/mL。配合物对大肠杆菌的抗菌活性高于对金黄色葡萄球菌。
AgEn (BigH) _2] _2 (SO_4) _3 · 7H_2O (3), [Ag (Py) _2 (N_2) _2] (OH) _2 was synthesized with ethylenebiguanide, pyridine and pyridine derivatives as ligands 4) and [Ag (2-Apy) _3 (OH)] (HSO_4) · H_2O (5). The product structure was characterized by IR, elemental analysis and XPS. The antibacterial ability of the complex was tested by the minimum inhibitory concentration (MIC) and growth inhibition curve, and the complex was tested for photostabilty. The results of antibacterial experiments showed that all the complexes started to inhibit the test bacteria at the concentration of 0.5μg / mL, the MICs of Escherichia coli were 10, 5 and 5μg / mL respectively, the MICs against Staphylococcus aureus were 40, 20 and 20 μg / mL. The antibacterial activity of the complex against Escherichia coli is higher than that against Staphylococcus aureus.