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目的探讨异基因造血干细胞移植(allo-HSCT)后白血病复发伴活动性移植物抗宿主病(GVHD)患者的临床效果。方法选取在我院接受allo-HSCT的白血病患者28例为研究对象,对患者原发病、疾病状态、白血病复发时GVHD特征进行分析观察。结果所有患者在allo-HSCT后复发时均存在活动性GVHD。发生allo-HSCT后复发患者与未复发患者在年龄、性别、供者性别匹配、移植前是否接受化疗、诊断-移植时间、移植时患者疾病程度和供者类型等方面对比差异无统计学意义,P>0.05。结论 allo-HSCT后白血病复发患者可依靠GVHD而获得缓解。
Objective To investigate the clinical effect of allogeneic hematopoietic stem cell transplantation (allo-HSCT) relapse with active graft-versus-host disease (GVHD). Methods Totally 28 patients with leukemia who received allo-HSCT in our hospital were selected as the research object to analyze the characteristics of GVHD in patients with primary disease, disease status and relapse of leukemia. Results All patients had active GVHD when relapsed after allo-HSCT. There was no significant difference in age, sex, gender of donor, chemotherapy before transplantation, diagnosis-graft time, the degree of disease at the time of transplantation and the type of donor after recurrence of allo-HSCT. P> 0.05. Conclusions Allo-HSCT patients with recurrent leukemia can be remitted by GVHD.