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衬贴于肝血窦的肝窦内皮细胞具有无隔膜的窗孔,并汇聚成肝筛。窗孔相当于可选择超滤系统,有利于调控肝细胞与肝窦血液的物质交换,尤其是在脂质代谢方面,窗孔结构异常是脂质代谢紊乱的重要因素。本文就窗孔的超微结构、开窗机制和调控因素以及与脂肪肝相关联系的进展做一综述。
Lining the sinusoidal sinusoidal endothelial cells with no diaphragm of the window, and converged into a liver sieve. The window is equivalent to the optional ultrafiltration system, which is conducive to the regulation of the material exchange between the liver cells and the hepatic sinus blood, especially in lipid metabolism. The abnormality of the pore structure is an important factor of lipid metabolism disorders. This review summarizes the ultrastructure of fenestration, the mechanism of fenestration and its regulatory factors, and the progress of the association with fatty liver.