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目的分析2型糖尿病并下肢血管病变患者中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinaseassociated lipocalin,NGAL)、同型半胱氨酸(homocysteine,Hcy)、高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)水平变化,探讨其与2型糖尿病并下肢血管病变的关系。方法 83例2型糖尿病患者依据下肢动脉彩色多普勒检查结果评分分组,评分为0分者21例为下肢动脉无病变组,评分<10分者21例为下肢动脉轻度病变组,评分为>10~20分者21例为下肢动脉中度病变组,评分>20分者20例为下肢动脉重度病变组,分别测定患者NGAL、Hcy、hs-CRP水平并进行组间比较。结果 NGAL、Hcy、hs-CRP水平有病变组均较无病变组增高,差异均有统计学意义(P<0.05),且随病变程度加重逐渐增高,组间两两比较差异均有统计学意义(P<0.05或P<0.01);NGAL、Hcy、hs-CRP水平与下肢病变程度呈正相关(r=0.661,P=0.000;r=0.612,P=0.000;r=0.647,P=0.000)。结论 NGAL、Hcy、hs-CRP水平对2型糖尿病患者下肢血管病变程度的评估有重要价值。
Objective To investigate the changes of neutrophil gelatinase associated lipocalin (NGAL), homocysteine (Hcy), high sensitivity C-reactive protein (TCR) in patients with type 2 diabetes mellitus and lower extremity vascular disease protein, hs-CRP) levels in patients with type 2 diabetes mellitus and lower extremity vascular disease. Methods Totally 83 patients with type 2 diabetes were divided into groups according to the results of color Doppler examination of lower extremity arteries. Twenty-one patients with score of 0 were lower extremity arterial non-lesion group, 21 patients with score less than 10 were lower extremity arterial lesion group, Twenty-one patients with> 10 to 20 points were moderate lower extremity arterial lesions, and 20 cases with score> 20 were lower extremity arterial lesions. The levels of NGAL, Hcy and hs-CRP were measured and compared between groups. Results The levels of NGAL, Hcy and hs-CRP were significantly higher in the lesion group than those in the non-lesion group (P <0.05), and increased gradually with the severity of the lesion. There was significant difference between the two groups (P <0.05 or P <0.01). The levels of NGAL, Hcy and hs-CRP were positively correlated with the degree of lower extremity lesions (r = 0.661, P = 0.000; r = 0.612, P = 0.000; r = 0.647, P = 0.000). Conclusion The levels of NGAL, Hcy and hs-CRP are of great value in the assessment of the degree of vascular lesions in type 2 diabetic patients.