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环核苷酸做为“第二信使”参与细胞内物质代谢过程,在低温应激状态中及体内脂类代谢上也起着重要作用。Bertin 等报告,大鼠棕色脂肪组织冷适应后环-磷酸腺苷(cAMP)下降,同时也发现田鼠的cAMP基础水平高。。Muirhead 和易华报告大白鼠长期寒冷暴露数周后,其尿中环核苷酸排出增加。Radomski 的研究指出,去北极之前,在15℃水中进行9天的浸泡锻炼后,可获得冷习服,表现为尿中去甲肾上腺素和cAMP没有显著改变。
Cyclic nucleotides, as second messengers, are involved in the metabolism of intracellular substances and play an important role in hypothermia and lipid metabolism in vivo. Bertin et al. Reported a decrease in cAMP after cold acclimation of brown adipose tissue in rats and a high cAMP basal level in the voles. . Muirhead and Iowa reported that after a long period of chronic cold exposure in rats, their urinary cyclic nucleotide excretion increased. According to Radomski’s study, cold acclimation was achieved after 9 days of soaking in water at 15 ° C before going to the North Pole, showing no significant changes in urinary norepinephrine and cAMP.