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目的 观察双氢青蒿素与甲氟喹联用治疗急性无并发症恶性疟疾的临床疗效。方法 以首日单剂双氢青蒿素 12 0mg顿服 ,次日及第三日甲氟喹 750mg及 50 0mg顿服的 3日疗法 ,治疗无并发症的恶性疟 54例 ,并于治疗后 1、2、3、4、7、14、2 1和 2 8天进行了随访。结果 54例患者经治疗后全部临床治愈 ,平均疟原虫转阴时间为 30 .7± 3.6小时。平均退热时间为 2 1.2± 2 .8小时 ,54例中 2例在疟原虫血症消失后第 2 1、2 5天复燃 ,复燃率 3.7% ;治愈率 96.3%。除少数病人发生轻微及短暂的恶心呕吐、纳差外 ,余未发现严重不良反应。结论 双氢青蒿素与甲氟喹联用 3日疗法治疗无并发症恶性疟疾具有良好疗效。
Objective To observe the clinical efficacy of dihydroartemisinin combined with mefloquine in the treatment of acute non-companied malignant malaria. Methods A single dose of dihydroartemisinin 120mg on the first day, the third day of the second and the third day of mefloquine 750mg and 50 0mg Dayton on the 3rd treatment of non-complication of falciparum malaria in 54 cases, and after treatment 1, 2, 3, 4, 7, 14, 21, and 28 days. Results All the 54 patients were cured after treatment. The average time of negative conversion of malaria was 30.7 ± 3.6 hours. The mean time to warm-off was 2 1.2 ± 2 .8 hours. Two of the 54 patients recovered from the second and twelfth day after the disappearance of Plasmodium falciparum with a rate of resurgence of 3.7% and a cure rate of 96.3%. In addition to a small number of patients with mild and transient nausea and vomiting, anorexia, I found no serious adverse reactions. Conclusion Dihydroartemisinin and mefloquine combined with 3-day treatment of non-companied malignant malaria has a good effect.