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本文报告了用33型 HLA 标准抗血清对45例Ⅲ期高血压病人,47例脑中风病人,57例健康人检测的结果。并以此两组病人分别与健康组比较其各型HLA 抗原出现的频率。结果Ⅲ期高血压病人组 CW6型抗原频率显著高于对照组。RR 为7.86,X~2值为8.4834,P<0.01;脑中风病人组 CW7型抗原频率显著高于对照组,RR 为24.75,X~2值为8.2502,P<0.01。这组脑中风病人多数有高血压史,且两组病人均以 C 组抗原(一为 Cw6,一为 Cw7)的频率显著高于对照组,对此调查结果应加重视,很有必要进一步研究。本文还详细地讨论了 HLA 与疾病相关机理的复杂性,并介绍了有关发病机理的几种学说。
This article reports the results of the detection of 45 patients with stage III hypertension, 47 patients with stroke and 57 healthy controls using type 33 HLA standard antiserum. And the two groups of patients were compared with the healthy group to compare the frequency of each type of HLA antigen. Results The frequency of CW6 antigen in patients with stage Ⅲ hypertension was significantly higher than that of the control group. RR was 7.86, X ~ 2 was 8.4834, P <0.01. The frequency of CW7 antigen in stroke patients was significantly higher than that in control group (RR = 24.75, X ~ 2 = 8.2502, P <0.01). The majority of stroke patients had a history of hypertension, and the frequency of C group antigen (Cw6, Cw7) in both groups was significantly higher than that in control group, so the investigation should pay more attention to it and it is necessary to further study . This article also discusses in detail the complexity of the mechanisms underlying HLA and disease and introduces several theories about the pathogenesis.