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目的 :探讨抗生素干预对血流感染患者的预后影响。方法:收集本院血流感染患者及其临床资料,依据是否抗生素干预将其分成对照组和干预组,并分析对血流感染患者的临床预后。结果:共纳入201例血流感染患者,对照组104例,干预组97例。对照组和干预组在经验用药比例无统计学差异(96.2% vs 92.8%,P=0.294),对照组恰当使用抗生素比例低于干预组(68.3% vs 81.4%,P=0.032)。干预组住院时间显著少于对照组[(18.9±16.5)vs(20.6±14.7),P=0.027],干预组30 d死亡率低于对照组(6.2% vs 14.4%,P=0.056)。结论:抗生素干预能够改善患者预后,降低住院时间和死亡率。
Objective: To investigate the influence of antibiotic intervention on the prognosis of patients with bloodstream infection. Methods: The patients with bloodstream infection in our hospital and their clinical data were collected and divided into control group and intervention group according to antibiotic intervention. The clinical prognosis of patients with bloodstream infection was analyzed. Results: A total of 201 cases of bloodstream infection were included in the control group, 104 cases in the intervention group and 97 cases in the intervention group. There was no significant difference between the control group and the intervention group (96.2% vs 92.8%, P = 0.294). The proportion of the appropriate antibiotics in the control group was lower than that in the intervention group (68.3% vs 81.4%, P = 0.032). The hospitalization time in the intervention group was significantly less than that in the control group (18.9 ± 16.5 vs 20.6 ± 14.7, P = 0.027). The 30-day mortality rate in the intervention group was lower than that in the control group (6.2% vs 14.4%, P = 0.056). Conclusion: Antibiotic intervention can improve prognosis and reduce hospitalization time and mortality.