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目的通过检测孕妇体内促甲状腺素(TSH)与甲状腺过氧化物酶抗体(TPOAb)的水平,探讨其在筛查孕妇发生甲状腺功能紊乱中的价值与意义。方法孕妇588例,甲状腺功能紊乱组79例;甲状腺功能正常组509例(高龄孕妇组88例,正常孕妇组421例),采用微粒子化学发光法分别检测并比较受试者的TSH、TPOAb水平。结果与甲状腺功能正常组相比,甲状腺功能紊乱组血清TSH与TPOAb水平高,差异具有统计学意义(P<0.05);正常孕妇组与高龄孕妇组比较,差异无统计学意义(P>0.05)。结论甲状腺功能检测指标TSH和TPOAb可以作为孕妇产前筛查的检测指标,预测孕妇发生甲状腺功能异常的风险。
Objective To investigate the value and significance of thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) in pregnant women to detect thyroid dysfunction in pregnant women. Methods 588 pregnant women, 79 cases of thyroid dysfunction group, 509 cases of normal thyroid function group (88 cases of advanced pregnant women group, 421 cases of normal pregnant women group), the level of TSH and TPOAb were detected and compared by microparticle chemiluminescence. Results Compared with normal thyroid function group, serum TSH and TPOAb levels were significantly higher in patients with thyroid dysfunction (P <0.05). There was no significant difference between normal pregnant women and advanced pregnant women (P> 0.05) . Conclusion Thyroid function test indicators TSH and TPOAb can be used as a prenatal screening test indicators to predict the risk of thyroid dysfunction in pregnant women.