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一、高龄妇女的内分泌变化 1.性激素:从性成熟期向老年期的过渡阶段称为更年期,卵巢改变最为明显,其重量从30岁开始急剧减轻,E_2、E_1量也从20～30岁的高峰急剧下降,至55岁后则更低。由于雌激素低下的负反馈,首先是FSH增高,继之LH亦增高,更年期的激素负荷试验表明下丘脑——垂体的反应性存在,激素的变化乃卵巢老化所致。 2.肾上腺系统:由肾上腺皮质产生的脱氢表雄酮、雄烯二酮(AD)随年龄增加而渐渐减少,绝经后血中的E_1、E_2大部分来自AD芳香化,血中的
1, endocrine changes in older women 1. Sex hormones: transitional period from sexual maturity to old men called menopause, the most obvious change in the ovaries, the weight began drastically reduced from the age of 30, E_2, E_1 amount from 20 to 30 years old The peak plummeted, even lower after age 55. Due to the negative feedback of low estrogen, the first increase in FSH, followed by LH also increased, menopausal hormone load test showed that hypothalamic-pituitary reactivity exists, hormonal changes caused by ovarian aging. 2. Adrenal system: the adrenal cortex produced by DHEA, androstenedione (AD) with age and gradually decreased, postmenopausal blood E_1, E_2 most of the blood from the AD aromatization