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目的:观察丁咯地尔治疗雷诺综合征(RS)的临床疗效。方法:将40例RS患者随机分为两组:对照组20例给予硝苯地平缓释片和哌唑嗪片口服;治疗组20例给予盐酸丁咯地尔静脉滴注治疗。观察2组患者肢端变色、疼痛等症状及冷水实验、握拳试验、血液流变学等实验室指标治疗前后的变化。结果:治疗组总有效95.0%,对照组总有效率65.0%,两组总有效率比较差异有统计学意义(P<0.05)。两组治疗后实验室指标比较差异也有统计学意义(P<0.05)。结论:丁咯地尔治疗RS疗效肯定,不良反应少。
Objective: To observe the clinical efficacy of buflomedil in the treatment of Raynaud’s syndrome (RS). Methods: Forty patients with RS were randomly divided into two groups: control group, 20 cases were given nifedipine sustained release tablets and prazosin tablets orally; treatment group, 20 cases were given buflomedil hydrochloride intravenous infusion. The changes of acromegaly, pain, cold water test, fist test, hemorheology and other laboratory indexes before and after treatment were observed in two groups. Results: The total effective rate was 95.0% in the treatment group and 65.0% in the control group. There was significant difference between the two groups in the total effective rate (P <0.05). The difference of laboratory indexes after treatment between the two groups was also statistically significant (P <0.05). Conclusion: Buflomedil treatment of RS positive effect, fewer adverse reactions.