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已证实电离辐射可损害肠道,它也常常是盆腔恶性肿瘤在接受放疗时剂量受到限制的原因。针对这种情况,寻找有效的预防措施,至为重要。本实验目的即在于研究使用要素餐预防狗胃肠道急性辐射伤的可能性。选择健康狗20条。体重18～20kg,不论雌雄均分为二组:A组喂以普通饲料,B组则以要素餐喂养。要素餐成份为:部分水解的高质量蛋白质(16.7%)。水解淀粉和蔗糖(73.9%),中链甘油三酯和红花油(9.5%)。每组又各抽出5条狗作为对照,并分别用原来配给的饲料至少喂养三天;然后,在麻醉下开腹取离回盲瓣约15cm的末端回肠作活检。余下的狗也分组喂养,三天后按治疗浸润性膀胱癌的标准给予总剂量2000 rad的放疗,照射膀胱区,分四天等量照完。
Ionizing radiation has been shown to damage the gut, and it is also often the reason that doses of pelvic malignancies are limited during radiotherapy. In view of this situation, it is very important to find effective preventive measures. The purpose of this experiment is to study the use of elemental meals to prevent the possibility of gastrointestinal acute radiation injury in dogs. Choose 20 healthy dogs. Weight 18 ~ 20kg, both male and female were divided into two groups: A group fed normal feed, B group was fed with essential meals. Essential meal ingredients are: partially hydrolyzed high quality protein (16.7%). Hydrolyzed starch and sucrose (73.9%), medium chain triglycerides and safflower oil (9.5%). Five dogs in each group were also selected as controls and fed separately for at least three days with the original ration. The distal ileum, approximately 15 cm apart from the ileocecal valve under anesthesia, was then biopsy-biopsy. The remaining dogs were also fed in groups. Three days later they were given radiotherapy at a total dose of 2000 rad according to the standard for the treatment of invasive bladder cancer. Irradiation of the bladder was performed in equal portions over four days.