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婴儿孤独症病因至今不明,可能因素众多,遗传因素和脑损伤可能是主要原因,血和血小板5-HT 测定提示可能有单胺能系统机能障碍。脑脊液(CSF)中单胺代谢的测定及中枢神经系统其他神经递质的测定也提示有此可能。婴儿孤独症的特征性症状是痛感减低和自伤。痛感由 CNS 的几种鸦片肽调节。
The etiology of infantile autism is still unknown and may be due to many factors. Genetic factors and brain damage may be the main reason. The determination of 5-HT level in blood and platelets may indicate dysfunction of monoaminergic system. Determination of monoamine metabolism in cerebrospinal fluid (CSF) and determination of other neurotransmitters in the central nervous system also suggest this possibility. The characteristic symptoms of infantile autism are reduced pain and self-injury. Pain is regulated by several opioid peptides of the CNS.