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Objective: To observe the efficacy of Shenmai injection in the treatment for adverse reactions of chemotherapy on advanced non-small cell lung cancer(NSCLC).Methods: 45 NSCLC patients with stages Ⅲb-IV were randomly divided into two groups: the treatment group(treated by chemotherapy combined with Shenmai injection)and the control group (treated by chemotherapy only).The efficacy of the two groups was evaluated after 3 cycles of treatment.Results: There was no significant difference between the two groups in the recent curative effects(P＞0.05), while there were significant differences between them in Karnofsky score and weight(P＜0.05).The treatment group was better than the control group in preventing leucopenia and decreased hemoglobin, and significant differences were found between them(P＜0.05).The incidence of thrombocytopenia, nausea and vomiting, hepatic and renal dysfunction in the treatment group was lower than that in the control group, but no significant differences were found between them(P＞0.05).Conclusion: Shenmai injection would not influence the efficacy of chemotherapy on advanced NSCLC patients, while it could improve the quality of life, increase the body weight of patients, alleviate adverse reactions of chemotherapy as myelosuppression so as to improve the tolerance of organism to chemotherapy.