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目的观察铝碳酸镁与多潘立酮联用治疗胆汁反流性胃炎临床效果。方法将我院消化内科收治胆汁反流性胃炎患者90例随机分为对照组与联用治疗组各45例,分别采用多潘立酮单和与铝碳酸镁联用治疗,疗程均为6周;比较两组患者治疗前后临床症状积分,治疗后24h胆汁反流次数及反流总时间百分比等。结果对照组与联用治疗组患者治疗后临床症状积分均明显优于治疗前,且联用治疗组患者临床症状积分改善明显优于对照组,组间比较差异显著(P<0.05);联用治疗组患者治疗后24h反流次数、反流总时间百分比均明显优于对照组,组间比较差异显著(P<0.05)。结论铝碳酸镁与多潘立酮联用治疗胆汁反流性胃炎可以有效改善临床症状,减少胆汁反流次数及时间。
Objective To observe the clinical effect of combination of aluminum magnesium carbonate and domperidone in the treatment of bile reflux gastritis. Methods A total of 90 patients with bile reflux gastritis were randomly divided into control group and combined treatment group (n = 45), treated with domperidone alone and combined with magnesium aluminum carbonate for 6 weeks respectively. The scores of clinical symptoms before and after treatment, the number of bile reflux and the percentage of total reflux time in 24h after treatment. Results The clinical symptom scores of the patients in the control group and the combined treatment group were significantly better than those before treatment, and the improvement of clinical symptom scores in the combined treatment group was significantly better than that in the control group (P <0.05) The number of reflux and the percentage of total reflux time in treatment group were significantly better than that in control group at 24 hours after treatment, with significant difference between the two groups (P <0.05). Conclusion Combined treatment of aluminum magnesium carbonate and domperidone in the treatment of bile reflux gastritis can effectively improve the clinical symptoms and reduce the frequency and time of bile reflux.