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成人急白68例(急淋20,非淋48例)随机分为服氟哌酸(Norflaxacin,NFA)组35例与服安慰剂对照组33例,双盲,对比观察,开始化疗至随后整个粒减(<500/mm~3)期服药400mg/12小时;此期病人大便中确定耐药G(-)菌时加用多粘菌素B,每二周一次大便细菌及霉菌培养,发热使用或更换抗生素前作血培养。化疗后两组粒减期相同,其中位时间32天;全部病例均曾发热,服NFA较对照组首次发热出现迟(6.3降至3.7天,P<0.05);发热时间短,(平均日数3.2与5.5天P<0.05),前者超过72小时7/35例,后者15/33例(P<0.03);粒减期总发热天数比例前者为27.6%,后者39.8%(P<0.05)。G(-)菌感染:服NFA组较对照组发生晚(10.5与5.3天,
A total of 68 adult patients with acute leukoplakia (acute lymphoid leprosy, non-leaching 48 cases) were randomly divided into taking norfloxacin (NFA) 35 patients and placebo control group of 33 patients, double-blind, comparative observation, Granule reduction (<500 / mm ~ 3) period of 400mg / 12 hours; during this period the patient identified in the stool of resistant G (-) bacteria with polymyxin B, biweekly stool bacteria and mold culture, fever Use or replace antibiotics for blood culture. After chemotherapy, the two groups had the same reduction of grain size with a median time of 32 days. All of the patients had fever. The incidence of NFA was delayed first (6.3 to 3.7 days, P <0.05) compared with that of the control group. The fever time was short (average day 3.2 And 5.5 days (P <0.05). The former was more than 7/35 cases in 72 hours and the latter 15/33 cases (P <0.03). The former was 27.6% and the latter 39.8% . G (-) bacterial infection: NFA group was later than the control group (10.5 and 5.3 days,