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为探索辣椒素类物质对小鼠的急性毒性伤害程度,为以后进行长期高剂量摄取辣椒素类物质的安全性研究提供基础数据,以蒸馏水和溶剂食用油作对照,辣椒素油溶液按6.08、27.14、46.23、200.41、461.08μg/kg·bw等5个剂量连续灌胃小鼠7d,试验剂量分别相当于人类日常摄入量的1.25、5、10、50、100倍。结果表明,给药期内小鼠饮食、活动、大小便均正常,毛泽光洁。最高剂量组死亡率超过50%,次高剂量组也有死亡,其他组则无死亡。中低剂量组与蒸馏水和食用油对照组相比,雌雄小鼠的摄食量和体重变化均未出现显著差异。
In order to explore the acute toxic injury of capsaicinoids to mice and provide the basic data for the safety study of long-term high-dose capsaicinoids, distilled water and solvent oil as control, the capsaicinoid oil solution was 6.08,27.14 , 46.23,200.41,461.08μg / kg · bw 5 consecutive doses of mice were intragastric administration of mice 7d, the test dose equivalent to human daily intake of 1.25,5,10,50,100 times. The results showed that the mice during the administration period, activity, urine and urine were normal, Mao Ze smooth. Mortality in the highest dose group exceeded 50%, in the second, high dose group, and in the other groups. Compared with distilled water and edible oil control group, there was no significant difference in food intake and weight between the low and middle dose groups.