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脑铁异常增高可能参与脑神经变性性疾病的发生发展。这一发现使得脑铁代谢成为近年广为关注和研究较为广泛的领域。本文综述了这一领域某些方面的目前认识，包括：（１） 脑铁分布及功能；（２） 转铁蛋白及转铁蛋白受体在脑内的合成与分布；（３） 脑铁摄取和运输。此外，对铁与某些金属离子，转铁蛋白和转铁蛋白受体与脑神经变性性疾病的关系，以及转铁蛋白受体内吞在生物大分子跨血脑屏障（ＢＢＢ） 运输中的作用也作了简要讨论。
Increased brain iron may be involved in the development of neurodegenerative diseases. This discovery makes brain iron metabolism has become a widespread concern in recent years and research areas. This review summarizes current understanding of some aspects of this area, including: (1) the distribution and function of brain iron; (2) the synthesis and distribution of transferrin and transferrin receptors in the brain; and (3) brain iron uptake And transport. In addition, the relationship between iron and certain metal ions, transferrin and transferrin receptors and neurodegenerative diseases and the role of transferrin receptor endocytosis in the transport of biological macromolecules across the blood-brain barrier (BBB) The role has also been briefly discussed.