缺血修饰白蛋白在冠心病临床应用的研究进展

• 作 者: 李丽 高大胜
• 机 构: 蚌埠医学院第一附属医院心血管科,
• 出 处: 国际内科学杂志
• 发表日期: 2008年09期
• 关键词: 缺血修饰白蛋白 冠心病 临床应用 心肌标志物

缺血修饰白蛋白(IMA)是血清白蛋白在经历缺血后形成的一种新的较理想的缺血标志物,对心肌损伤的诊断有较高的敏感性,检测技术成熟,检验方法简易快捷,成本不高。多项临床实验研究显示,IMA在冠心病领域中,特别是在急性冠状动脉综合征的诊断、危险分层以及治疗方案的制订中具有重要意义。另有一些研究提示:IMA可能对接受经皮冠状动脉介入术的冠心病患者预后有一定预测价值;IMA在冠状动脉痉挛诱发的短暂心肌缺血中也可能有一定意义;IMA水平可能与心功能的分级有一定的相关性。IMA作为一个优秀的心肌缺血指标,还需要更深入的研究以确定它在冠心病领域中广阔的临床应用价值。

Ischemia-modified albumin (IMA) is a new ideal ischemic marker of serum albumin after being subjected to ischemia. It has a high sensitivity to the diagnosis of myocardial injury. The detection technique is mature and the test method is simple Fast, the cost is not high. A number of clinical trials have shown that IMA plays an important role in the field of coronary heart disease, especially in the diagnosis of acute coronary syndromes, risk stratification and treatment planning. Other studies suggest that IMA may have some predictive value in the prognosis of patients with coronary artery disease undergoing percutaneous coronary intervention. IMA may also have some significance in transient myocardial ischemia induced by coronary artery spasm. IMA may be associated with cardiac function The classification of a certain degree of relevance. IMA as a good indicator of myocardial ischemia, but also need more in-depth study to determine its broad clinical application in the field of coronary heart disease.