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目的探讨中晚期宫颈癌患者贫血程度对根治性放射治疗预后的影响。方法 128例中晚期宫颈癌患者行根治性放射治疗,体外照射总剂量50 Gy及高剂量率后装治疗总剂量42 Gy。患者均在放疗前及放疗中进行血红蛋白水平测定,了解其与宫颈癌局部控制率及远期疗效的关系。结果放疗前血红蛋白水平越低,放疗后肿瘤局部控制率及5 a生存率均越低(P<0.01);放疗中,血红蛋白水平升高组完全缓解率及5 a生存率均较降低组高(P<0.01,P<0.05)。结论血红蛋白水平影响宫颈癌的局部控制率和远期疗效,放疗前纠正贫血有助于宫颈癌患者预后。
Objective To investigate the effect of anemia in patients with advanced cervical cancer on the prognosis of radical radiotherapy. Methods A total of 128 patients with advanced cervical cancer underwent radical radiotherapy. The total dose of radiation was 50 Gy and the dose of 42 Gy was loaded after high dose rate. Patients were measured before and during radiotherapy hemoglobin levels, to understand its relationship with local control of cervical cancer and long-term efficacy. Results The lower the hemoglobin level before radiotherapy, the lower the local control rate and 5-year survival rate after radiotherapy (P <0.01). In radiotherapy, the complete remission rate and the 5-year survival rate of hemoglobin increased significantly P <0.01, P <0.05). Conclusion The hemoglobin level affects the local control rate and long-term curative effect of cervical cancer. Correcting anemia before radiotherapy is helpful to the prognosis of cervical cancer patients.