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目的探讨血清超氧化物歧化酶变化与卵巢恶性肿瘤发生、发展的关系。方法采用黄嘌呤氧化酶法对 2 6例卵巢恶性肿瘤患者及3 0例卵巢良性病变患者 ,以及 16例正常人进行血清总超氧化物歧化酶 (T-SOD) ,锰超氧化物歧化酶 (Mn-SOD)测定。结果卵巢恶性肿瘤患者 T-SOD,Mn-SOD活性降低 ,与正常人相比有显著性差异 (P<0 .0 5 ,P<0 .0 1)。卵巢良性病变患者 T-SOD,Mn-SOD活性降低 ,但与正常人相比无显著性差异 (P>0 .0 5 )。Mn-SOD在卵巢良恶性两组间有显著性差异 (P<0 .0 5 )。卵巢恶性肿瘤不同组织类型间及早期与晚期间差异均无显著性意义。结论卵巢恶性肿瘤患者体内抗氧化能力下降 ,Mn-SOD可作为检测卵巢良、恶性的一个非特异性指标
Objective To investigate the relationship between the changes of serum superoxide dismutase and the occurrence and development of ovarian cancer. Methods Twenty-six cases of ovarian cancer and 30 cases of benign ovarian disease, as well as 16 healthy controls were studied by xanthine oxidase method. Serum total superoxide dismutase (T-SOD), manganese superoxide dismutase Mn-SOD) assay. Results T-SOD and Mn-SOD activity in patients with ovarian cancer were significantly lower than those in normal controls (P <0.05, P <0.01). The activity of T-SOD and Mn-SOD in patients with benign ovarian disease was decreased, but there was no significant difference compared with normal people (P> 0.05). Mn-SOD in ovarian benign and malignant between the two groups were significantly different (P <0. 05). There was no significant difference between different tissue types of ovarian cancer and between early and late stages. Conclusion Ovarian malignant tumors in vivo antioxidant capacity decreased, Mn-SOD can be used as a detection of ovarian benign and malignant of a non-specific index