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目的 探讨瘦素、胰岛素在妊娠期高血压疾病 (妊高征 )发病中的意义及相互关系。方法 2 0 0 1年 1月至 2 0 0 2年 12月 ,采用放射免疫法对 30例妊娠期高血压疾病患者 ,30例正常孕妇的血清瘦素、胰岛素进行测定 ,并测定孕妇血压及尿蛋白含量 ,同时测定其新生儿脐血清瘦素、胰岛素水平。结果 妊娠期高血压疾病患者血清瘦素与胰岛素水平均明显高于对照组 (P <0 0 1)。妊娠期高血压疾病患者血清瘦素与胰岛素呈正相关(r =0 4 6 )。妊娠期高血压疾病患者血清瘦素水平与尿蛋白含量呈正相关 (P <0 0 5 ) ,与血压无明显相关性 (P>0 0 5 )。结论 孕妇血清瘦素水平可作为反映妊娠期高血压疾病患者胎盘缺氧严重程度即病情严重程度的潜在临床指标。妊娠期高血压疾病患者血清胰岛素与瘦素水平呈正相关 ,两者共同参与妊娠期高血压疾病的发病。
Objective To investigate the significance and relationship between leptin and insulin in the pathogenesis of pregnancy-induced hypertension (PIH). Methods From January 2001 to December 2002, serum leptin and insulin levels were measured in 30 pregnant women with hypertensive disorder complicating pregnancy and 30 normal pregnant women by radioimmunoassay. Blood pressure and urine of pregnant women were measured. Protein content, simultaneous determination of neonatal umbilical serum leptin, insulin levels. Results The levels of serum leptin and insulin in patients with gestational hypertension were significantly higher than those in the control group (P <0.01). Serum leptin was positively correlated with insulin in patients with gestational hypertension (r = 0 46). There was a positive correlation between serum leptin level and urine protein level in patients with gestational hypertension (P <0.05), but no significant correlation with blood pressure (P> 0.05). Conclusion The level of serum leptin in pregnant women can be used as a potential clinical indicator to reflect the severity of placental hypoxia, which is the severity of the disease in patients with gestational hypertension. Serum insulin levels in patients with gestational hypertension are positively correlated with leptin levels, both of which participate in the pathogenesis of hypertensive disorder complicating pregnancy.