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目的探讨丹参联合柳氮磺胺吡啶(SASP)在治疗溃疡性结肠炎中的作用及对细胞因子IL-6的影响。方法将60例溃疡性结肠炎患者随机分为治疗组和对照组各30例,对照组给予口服柳氮磺胺吡啶治疗,治疗组在此基础上加用丹参粉口服。8周后比较IL-6的变化、内镜及组织学疗效。结果对照组与治疗组内镜下炎症程度改善总有效率分别为73.3%和90%,两组比较差异有统计学意义(P<0.01);组织学炎症改善总有效率分别为73.3%和90%。两组比较差异有统计学意义(P<0.01);治疗组炎症细胞因子IL-6下降水平明显低于对照组(P<0.05),而且IL-6的下降与内镜及组织学的改善呈正相关。结论丹参联合SASP治疗溃疡性结肠炎能明显降低炎症细胞因子IL-6水平,且在内镜及组织学上的改善更优于对照组。
Objective To investigate the effect of Salvia miltiorrhiza combined with sulfasalazine (SASP) in the treatment of ulcerative colitis and its effect on cytokine IL-6. Methods Sixty patients with ulcerative colitis were randomly divided into treatment group (30 cases) and control group (30 cases). Patients in the control group were treated with sulfasalazine orally. On the basis of this study, the treatment group was given Salvia miltiorrhiza powder orally. The changes of IL-6, endoscopic and histological efficacy were compared after 8 weeks. Results The total effective rates of endometrial inflammation in control group and treatment group were 73.3% and 90%, respectively, with significant difference between the two groups (P <0.01). The total effective rate of histological inflammation improvement was 73.3% and 90% respectively %. The difference between the two groups was statistically significant (P <0.01); the treatment group inflammatory cytokines IL-6 decreased significantly lower than the control group (P <0.05), and IL-6 decreased and endoscopic and histological improvement was positive Related. Conclusion Salvia combined with SASP treatment of ulcerative colitis can significantly reduce the level of inflammatory cytokines IL-6, and endoscopic and histological improvement is better than the control group.