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环氧化酶-2(cyclooxygenase-2,COX-2)是催化花生四烯酸代谢的关键酶。最早有关COX-2与肿瘤关系的研究是从人群流行病学研究开始的。1988年发现长期口服阿司匹林可以降低人群中结肠癌的发病率。由于COX-2表达异常与结直肠癌发生的密切相关,以及非甾体抗炎药(non steroidalanti-i
Cyclooxygenase-2 (COX-2) is a key enzyme that catalyzes the metabolism of arachidonic acid. The earliest research on the relationship between COX-2 and tumors began with population epidemiological studies. Long-term oral aspirin was found in 1988 to reduce the incidence of colon cancer in the population. Because of the abnormal expression of COX-2 and colorectal cancer are closely related, and non-steroidal anti-inflammatory drugs (non steroidalanti-i