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酸性鞘磷脂酶-神经酰胺信号通路的激活与许多疾病的发生密切相关,酸性鞘磷脂酶已成为多种疾病的生物标记物及潜在重要的治疗靶标,因此其抑制剂研究也备受关注。简介与酸性鞘磷脂酶相关的疾病,分类综述酸性鞘磷脂酶抑制剂的研究近况,为高活性、高选择性酸性鞘磷脂酶抑制剂的研究与开发及用于相关疾病的预防和治疗提供参考。
Activated sphingomyelinase - ceramide signaling pathway is closely related to the occurrence of many diseases. Acidic sphingomyelinase has become a biomarker of many diseases and a potentially important therapeutic target. Therefore, the research on its inhibitors is also of great concern. Brief introduction Acid sphingomyelinase-related diseases, classification Review Acid sphingomyelinase inhibitors recent research, high activity, high selectivity of acidic sphingomyelinase inhibitors of research and development and for the prevention and treatment of related diseases provide a reference .