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[Xie M,et al.Cancer Res,2016,76(21):6340-6350]尽管在前列腺癌诊断和治疗方面已经取得了巨大进步,但其依然是欧美男性中发病率最高的癌症,癌症致死率高居第二。在我们早期研究中发现了一种在前列腺癌中高表达的RNA解旋酶基因——DDX3,并发现它的表达越高,癌细胞的侵袭越强。在侵袭性前列腺癌细胞系中,敲除DDX3可以明显减少集落生成。因此,我们设计了一种可以特异性针
[Xie M, et al. Cancer Res, 2016,76 (21): 6340-6350] Although great progress has been made in the diagnosis and treatment of prostate cancer, it remains the most prevalent cancer in both men and women in Europe and has caused cancer death Rate second highest. In our earlier study, we found an RNA helicase gene that is highly expressed in prostate cancer, DDX3, and found that the higher the expression, the stronger the invasion of cancer cells. Knockout of DDX3 significantly reduced colony formation in aggressive prostate cancer cell lines. So we designed a needle that can be specific