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目的；分析自身抗体和干扰素抗体在慢性病毒性肝炎患者干扰素治疗时的检出情况及其与治疗效果的关系。方法：自身抗体的检测为间接免疫荧光法；应用酶免疫法测定干扰素抗体之总抗体。结果：（1）与正常人相比，患者自身抗体及干扰素抗体阳性率明显增高（P＜0．01），而且干扰素抗体在慢乙肝及慢丙肝患者中存在显著性差异（P＜0．05）；（2）自身抗体的存在与否和疗效无相关性（P＞0．05），干扰素抗体在治疗前已阳性和治疗后才转阳的患者，对干扰素治疗的反应可能有一定差异。结论：对于慢性病毒性肝炎患者来说，自身抗体及干扰素抗体的出现并不绝对意味着干扰素治疗效果的好坏。
Objective To analyze the detection of autoantibodies and interferon antibodies in the treatment of patients with chronic viral hepatitis interferon and its relationship with the treatment effect. Methods: The autoantibodies were detected by indirect immunofluorescence. The total antibody of interferon antibody was determined by enzyme immunoassay. Results: (1) The positive rates of autoantibodies and interferon antibodies in patients with chronic hepatitis B and chronic hepatitis C were significantly higher than those in normal controls (P <0.01) .05). (2) There was no correlation between the presence and absence of autoantibodies and efficacy (P> 0.05). The response of interferon to interferon therapy in patients who had been positive before treatment and turned positive after treatment was There are some differences. CONCLUSIONS: The appearance of autoantibodies and interferon antibodies in patients with chronic viral hepatitis does not necessarily mean that interferon is effective.