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The effect of branching on the blood circulation and tumor targeting of polymer nanovehicles in vivo was investigated in this study.For the purpose,star-branched poly(lactic acid)and poly(2-methacryloyloxyethyl phosphorylcholine)(PLA-PMPC)copolymers with umbrella-type AB3,(AB3)2,and(AB3)3 architecture were synthesized by branching at the PLA core.Micelles self-assembled from these copolymers were used to evaluate the effect of core branching on blood circulation and tumor targeting.The results showed that branching changed the behavior of polymeric self-assembly in solution,thereby changing the size and surface anti-fouling performance of the polymeric micelles.Moreover,star-branched copolymer micelles with a higher branching degree allowed their payload to persist better in blood(half-time prolonged from 7.1,8.6 to 13.8 h)and for a 1.72-fold higher content at the tumor site.These studies suggest that raising the branching degree of amphiphilic copolymer potentially offers a promising strategy for the design of carriers capable of enhanced circulation and targeting in vivo.