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目的探讨单硝酸异山梨酯治疗慢性肺心病肺动脉高压的临床疗效。方法选择2014年7月—2015年12月于东台市人民医院就诊的78例慢性肺心病肺动脉高压患者,根据治疗方法的不同分为观察组和对照组,各39例。对照组给予常规治疗,观察组在此基础上给予单硝酸异山梨酯。比较两组患者的临床疗效、血气分析指标[p H值、动脉血氧分压(PaO_2)和动脉血二氧化碳分压(Pa CO2)]和不良反应发生情况。结果观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗前两组患者p H值、PaO_2和Pa CO2比较,差异无统计学意义(P>0.05)。治疗后观察组PaO_2高于对照组,Pa CO2低于对照组,差异有统计学意义(P<0.05)。两组均未发生血压下降以及其他严重不良反应,观察组2例患者出现轻度头疼,停药后头痛消失。结论单硝酸异山梨酯治疗慢性肺心病肺动脉高压临床疗效确切,可明显改善患者的血气分析指标。
Objective To investigate the clinical efficacy of isosorbide mononitrate in the treatment of chronic pulmonary heart disease with pulmonary hypertension. Methods From July 2014 to December 2015, 78 patients with chronic pulmonary heart disease who were treated in Dongtai People’s Hospital were divided into observation group and control group according to different treatment methods, 39 cases in each group. The control group was given routine treatment, the observation group was given isosorbide mononitrate on the basis of this. The clinical efficacy, blood gas analysis indicators [p H value, PaO 2 and PaCO 2] and adverse reactions were compared between the two groups. Results The clinical efficacy of observation group was better than that of control group, the difference was statistically significant (P <0.05). There was no significant difference in p H value, PaO 2 and PaCO 2 between the two groups before treatment (P> 0.05). After treatment, the PaO_2 in the observation group was higher than that in the control group, PaCO 2 was lower than the control group, the difference was statistically significant (P <0.05). No hypotension and other serious adverse reactions occurred in either group. Two patients in the observation group had mild headache and their headache disappeared after withdrawal. Conclusions Isosorbide Mononitrate is effective in treating pulmonary hypertension due to chronic pulmonary heart disease and can significantly improve the blood gas analysis index of patients.