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目的:观察仙灵骨葆对犬种植体周围炎龈沟液中白细胞介素-1(IL-1)、白细胞介素-6(IL-6)含量的影响,以此评判仙灵骨葆对种植体周围炎的治疗作用。方法:把参与犬分为对照组、实验组,将实验组建立种植体周围炎模型,而后实验组再随机分为中药组和盐水组,各组均于给药时(基点)和基点后1、4、8、12、16周采集种植体周围龈沟液,并测定IL-1、IL-6含量。结果:(1)实验组菌斑指数、探诊深度、牙龈指数均明显高于对照组,差异具有显著性意义(P<0.01),成功复制犬种植体周围炎动物模型;(2)中药组龈沟液中IL-1、IL-6含量于8周开始显著下降,到16周时同对照组相比无明显差异(P>0.01),盐水组龈沟液中IL-1、IL-6含量始终处于较高水平,同对照组有明显差异(P<0.01)。结论:仙灵骨葆可以有效的降低犬种植体周围炎龈沟液中IL-1、IL-6的表达,达到治疗的目的。
Objective: To observe the effects of Xiongsuguibao on interleukin-1 (IL-1) and interleukin-6 (IL-6) in gingival crevicular fluid around implant in dogs, Therapeutic effect of peri-implantitis. Methods: Participating dogs were divided into control group and experimental group, the experimental group was established peri-implantitis model, and then the experimental group was randomly divided into traditional Chinese medicine group and saline group, each group were administered (base point) and 1 At 4, 8, 12 and 16 weeks, the gingival crevicular fluid around the implant was collected and the levels of IL-1 and IL-6 were measured. Results: (1) The plaque index, probing depth and gingival index in the experimental group were significantly higher than those in the control group (P <0.01). The animal models of peri-implant inflammation were successfully replicated. (2) The content of IL-1 and IL-6 in gingival crevicular fluid decreased significantly from 8 weeks to 16 weeks and there was no significant difference between the two groups (P> 0.01). The concentrations of IL-1 and IL-6 Content was always at a high level, with the control group were significantly different (P <0.01). Conclusion: Xianling Gubao can effectively reduce the expression of IL-1 and IL-6 in gingival crevicular fluid around canine implant, and achieve the goal of treatment.