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目的研究抑癌基因PTEN和凋亡抑制基因Livin在宫颈癌中表达及与淋巴结转移的关系。方法应用免疫组化法检测68例宫颈癌组织及16例正常宫颈组织中PTEN和Livin蛋白的表达情况。结果宫颈癌组织中,PTEN蛋白阳性表达率显著低于正常宫颈组织的表达(P<0.01),与淋巴结转移呈负相关(P<0.05);Livin蛋白阳性表达率显著高于正常宫颈组织的表达(P<0.01),与淋巴结转移呈正相关(P<0.05);PTEN和Livin蛋白在癌组织中表达呈负相关。结论 PTEN和Livin蛋白表达改变与宫颈癌的发生、发展及淋巴结转移密切相关。
Objective To study the relationship between the expression of tumor suppressor gene PTEN and apoptosis inhibitor Livin in cervical cancer and their relationship with lymph node metastasis. Methods The expressions of PTEN and Livin protein in 68 cases of cervical cancer and 16 cases of normal cervical tissue were detected by immunohistochemistry. Results The positive expression rate of PTEN protein in cervical cancer tissues was significantly lower than that in normal cervical tissues (P <0.01) and negatively correlated with lymph node metastasis (P <0.05). The positive expression rate of Livin protein in cervical cancer tissues was significantly higher than that in normal cervical tissues (P <0.01), and positively correlated with lymph node metastasis (P <0.05). The expression of PTEN and Livin in cancer tissue was negatively correlated. Conclusion The changes of PTEN and Livin protein expression are closely related to the occurrence and development of cervical cancer and lymph node metastasis.