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目的观察东菱迪芙治疗糖尿病周围血管病变疗效。方法选择32例2型糖尿病周围血管病变病人.在应用饮食控制及口服降糖药或注射胰岛素基础上,用东菱迪芙一般每周给药3次,隔日1次,首次l0U,以后5U溶于100ml～250ml生理盐水内稀释,静脉点滴l小时以上。3～5次为一疗程,根据病情轻重可重复2～3疗程。每疗程间隔3天。期间停用使用其他扩血管药物。治疗前后行双下肢动脉彩色多普勒超声检查。同时采用动态血糖监测系统(CGMS,Mini Med Inc)对本组受试者进行连续的血糖监测。结果1.治疗后股动脉、颈动脉、足背动脉管径和血流量均较治疗前有明显改善。两组治疗前后比较,有明显差异(P<0.01)。2.每日用药一次24h血糖水平曲线较不用药者血糖水平曲线明显低平(P<0.001)。结论东菱迪芙治疗糖尿病周围血管病变是一种较安全有效的治疗方法。
Objective To observe the curative effect of Donglingdufu on diabetic peripheral vascular disease. Methods 32 patients with peripheral vascular disease of type 2 diabetes mellitus were selected.On the basis of diet control and oral hypoglycemic agents or insulin injections, the drug was administered three times a week, once daily for the first time, and then for 5U Diluted in 100ml ~ 250ml saline, intravenous drip more than l hour. 3 to 5 times for a course of treatment, according to the severity of the disease can be repeated 2 to 3 courses. Each treatment interval of 3 days. During the deactivation of other vasodilators. Color Doppler ultrasound examination of both lower extremity arteries before and after treatment. At the same time, continuous glucose monitoring was performed on this group of subjects using the Dynamic Blood Glucose Monitoring System (CGMS, Mini Med Inc). Results 1. After treatment, the femoral artery, carotid artery, dorsalis pedis artery diameter and blood flow were significantly improved than before treatment. There was a significant difference between the two groups before and after treatment (P <0.01). (2) Daily 24 h blood glucose level curve was significantly lower than the non-use blood glucose level curve (P <0.001). Conclusion Donglingdufu treatment of diabetic peripheral vascular disease is a more safe and effective treatment.