论文部分内容阅读
通过心率变异性和血压变异性的频谱分析，计算以血压为输入，心搏间隔为输出的传递函数。以传递函数的模量作为压力发射敏感性（Ｂａｒｏｒｅｆｌｅｘｓｅｎｓｉｔｉｖｉｔｙ，ＢＲＳ）的指标。采用蜂鸣噪声和电击引起大鼠应激，使其血压升高。实验中记录血压信号。并在侧脑室注射血管升压素Ｖ１受体阻断剂。结果：１、高血压组的ＢＲＳ在极低频和低频段明显低于正常血压大鼠；２、侧脑室注射血管升压素Ｖ１受体阻断剂后，正常大鼠的ＢＲＳ无显著性改变，而高血压组的血压波动明显增大，ＢＲＳ的极低频段比对照状态进一步减小。实验提示：１、应激致高血压的过程中，血压升高引起压力感受器重调定，导致ＢＲＳ降低；２、血管升压素对压力发射的易化作用可能主要通过中枢Ｖ１受体介导，Ｖ１受体的阻断导致ＢＲＳ的降低。由ＢＲＳ的谱分析为进一步研究无创伤临床检测手段提供了基础
Through the frequency analysis of heart rate variability and variability of blood pressure, the transfer function with blood pressure as input and heartbeat interval as output was calculated. The modulus of the transfer function is used as an indicator of baroreflex sensitivity (BRS). Buzzing noise and electric shocks cause stress in rats and raise their blood pressure. Blood pressure signals were recorded during the experiment. And in the lateral ventricle injection of vasopressin V1 receptor blockers. BRS in hypertensive group was significantly lower than that in normal blood pressure in the very low frequency and low frequency range; 2. BRS did not change significantly in normal rats after intracerebroventricular injection of vasopressin V1 receptor blocker, However, the fluctuation of blood pressure in hypertensive group was significantly increased, and the extremely low frequency band of BRS was further reduced compared with the control. Experimental tips: 1, the process of stress-induced hypertension, blood pressure caused by baroreceptor re-adjust, resulting in decreased BRS; 2, vasopressin on the pressure transmitter facilitation may be mainly through the central V1 receptor-mediated Blocking of V1 receptors leads to a decrease in BRS. Spectral analysis by BRS provides the basis for further study of noninvasive clinical detection methods