【摘 要】
：
促分裂原活化的蛋白质激酶(mitogen-activated protein kinase,MAPK)级联是广泛存在于真核生物中的高度保守的信号转导途径.MAPK级联由MAPKKK (MEKK)、MAPKK(MEK或MKK)和MAPK三种蛋白质激酶组成.当细胞应答发育信号或者环境胁迫时,MAPK级联组分通过依次磷酸化被顺序激活,通过活化的MAPK磷酸化靶蛋白质,改变靶蛋白质的活性,将信号传递下去.MAPK级联在真核生物信号转导过程中发挥至关重要的作用,通过以复杂的信号传递网络形式整合多种外源和内源信号,涉
【机 构】
：
河南师范大学生命科学学院分子细胞生物学研究室,河南,新乡453007
论文部分内容阅读
促分裂原活化的蛋白质激酶(mitogen-activated protein kinase,MAPK)级联是广泛存在于真核生物中的高度保守的信号转导途径.MAPK级联由MAPKKK (MEKK)、MAPKK(MEK或MKK)和MAPK三种蛋白质激酶组成.当细胞应答发育信号或者环境胁迫时,MAPK级联组分通过依次磷酸化被顺序激活,通过活化的MAPK磷酸化靶蛋白质,改变靶蛋白质的活性,将信号传递下去.MAPK级联在真核生物信号转导过程中发挥至关重要的作用,通过以复杂的信号传递网络形式整合多种外源和内源信号,涉及生长、发育、分化和应激等过程.已有研究显示,MAPK级联参与了植物生长发育、生物和非生物胁迫应答以及激素信号转导等过程.近年来,随着基因编辑技术、蛋白质相互作用技术以及磷酸化分析等技术的发展,水稻MAPK级联的鉴定和功能研究取得较大进展.本文概述了水稻MAPK级联的组成和分类,重点综述了水稻MAPK级联在粒型、粒数和休眠控制中的作用,以及在水稻基础免疫、稻瘟病、白叶枯病等生物胁迫中,低温、干旱、盐胁迫和创伤等非生物胁迫响应中的功能,讨论了MAPK级联和植物激素信号关系的研究现状,并就MAPK级联研究的前景和存在的主要问题进行了展望和分析,旨在为水稻MAPK级联的研究提供参考.
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